I need some Christian advice please!?

I have a friend (and by friend I mean I really have a friend ) who suffers from low self esteem. She is heavy (5'4 and about 230lbs) and has Polycystic Ovarian Syndrome which causes her to have wierd patches of hair on her (that no one can see). So her attitude stinks most of the time and she has a hard time trusting people from church because she's been hurt so much in the past (people making fun of her, etc..). How can she learn how to open up and not be full of anxiety? She is 24, married, no kids. Husband doesn't go to church with her. This is serious so no rudeness please!